Tag Archives: chemistry

The Shulgin Index, Vol. I: Now Available!

The Shulgin Index – Volume One: Psychedelic Phenethylamines and Related Compounds is the latest work by Sasha Shulgin, the world’s most prolific explorer of the chemistry and effects of psychedelic drugs. It is a comprehensive survey of the scientific literature on the known psychedelic phenethylamines and related compounds, an invaluable resource for research pharmacologists, physicians, chemists, and law enforcement.

Included in this book:

•  A structure-oriented survey of psychedelic phenethylamines, amphetamines, phenylpiperazines, and other similar compounds. Structure-activity relationships are emphasized throughout.
•  Treatment of 126 main compounds with detailed physical properties, syntheses and analytical chemistry, biochemistry, pharmacological properties, and legal status. Fully referenced with over 2,000 citations.
•  Sub-tables of lesser-studied structural homologues and analogues.  Over 1400 total compounds covered.
•  Extensive cross-referencing tables for rapid location of key information.

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Order by Mail:
P.O. Box 13675 . Berkeley, CA . 94712
Fax: (925) 934-5999 . Voice Mail: (925) 934-2675
List Price: $85.00 . Sales Tax (CA only) $7.86

Ann’s Update: 28 Jan 2011

Dear People All over the World, including China, unless the people in China are among those who believe that Tibet is better off as part of China than before they were part of China. Although I don’t wish to alienate any nice people in China, they must understand that I am a devoted admirer of the Dalai Lama and all the people of Tibet who resisted the invasion of Big Brother China.  I would not have expanded on this except for Greg, who always puts my writing onto Caring Bridge and Facebook, and who phoned me today when I was driving in town (without my head set) and asked me (referring to yester– oops — several days ago, when my salutation included the words, “except the people of China,” or something like that), and asked me, “Why?”

My reply was rather scattered, since a corner of my mind was busy trying to identify possible policemen or other law enforcement who might notice that I wasn’t talking into a headset, and subsequently levy upon me a fine of huge proportions.  And they would be right.  I believe in headsets while driving and also while not driving, and I own two of them, but don’t know where they are at the moment.

Since then, I’ve reviewed the part of my brain that contains files called “China and Tibet,” and re-affirmed my strong feelings about that subject.  That’s why you are being subjected to all this.  I’m out of the China closet.  Actually, that used to be (in the late 1800’s) called the China cabinet, but —- Never Mind.

Where was I?

Oh, yes.  Hello, Dear People of Everywhere,

Today was one of the Big Days.  Sasha actually walked all the way to the lab, and took his seat inside, with his caregiver present, and began talking chemistry with Paul, who took some fantastic photos.  Tania joined them at one point, and there is a great picture of all three of them, smiling broadly.

We are (meaning the two girls/women/ladies and I) gradually getting a picture — sort of — of Sasha’s pain problems, the where and the why.  His Achilles tendon and the heel have become almost-perfect examples of superb Western medicine and what can be done by really good Western surgeons.  The original angels are, of course, Drs. Howard Kornfeld and Paul Abramson, who pointed us in the direction of said surgeons.  Without them, we would never have heard of doctors who label themselves “Limb Savers,” and we probably would have lost a foot by now.  And, yes, we all would have lost that foot.

In the evenings, Sasha’s needle pains attack his leg, and they are now being understood as the results of the peripheral neuropathy, and he’ll probably continue having that problem.  We’ll do our best to make him as healthy as possible by means of diet (fresh fruits and veggies, protein, vitamins, etc.) as well as exercise.  Following the advice of a very wise person, we’re giving him goat’s milk and Basmati rice, and these do actually help reduce swelling in his feet, which is a real concern.  But we’re all still learning.  Every night is a bit different.  When he can be persuaded to stay in bed most of the night, the foot swelling is gone by morning.  When his pain makes it necessary for him to sleep in the Lazyboy chair, the swelling is still present when he wakes up.  But all of it is getting better.

Sasha’ mental state seems to have improved during the day, since he came home from hospital, but the “sundowning” is almost always present, to some extent, by the time evening comes.  His chemical knowledge is still there, though, and now that he can work in the lab with Paul, it will probably sharpen and improve, along with his analytical ability and other aspects of his mental functioning.  But he can’t be left alone, because there’s too much risk of falling, among other things.  So we continue to fund-raise, because we’ll need 24-hour a day help for the rest of Sasha’s life.  So far, as I’ve said many times, we’ve been amazingly lucky in our caregivers, with perhaps a single exception, but we’re busy taking care of that exception.  We seem to have attracted really lovely human beings — funny and caring and patient — and may it continue to be so.  With Tania and Greg as our right and left arms, all we can do is give thanks (and feed them all Basmati rice).

For the moment, this is all.  When Greg returns from his mother’s funeral, I’ll write more.

Love and thanks to all of you.  Sleep well and dream in color (unless you don’t want to).    Ann

Ann’s Update: 3 Jan 2011

Dear Friends,

Finally, we have the really great news we’ve been waiting for!  Sasha’s left foot has been encased in a wound vac. for five days, and yesterday, on the fifth day, the vascular surgeon, a terrific man named Dr. Parrett, took the vacuum off and examined the graft site.  He said it had taken, hooray and Amen.  Until now, we had not been able to dismiss completely the possibility of amputation, but this tells us that (at least, for the foreseeable future), the foot will remain with the rest of Sasha’s bod.  And, thank heaven, Sasha can come home on Wednesday!

This particular hospital experience has not been without problems.  We never did get a private room, due to the patient overload, but for the most part, the other room-mates have been nice people, so that isn’t a complaint. The nurses are mostly very nice and pleasant and helpful, with a few inevitable exceptions, who made things a bit difficult for our caregivers, probably not realizing that we have a really good relationship with our three caregivers and that they tell us everything that goes on when we aren’t there.  Including what certain nurses say about a lot of things in our absence that they did not — and would not — say when we’re there.  A lot of funny stuff, nit-picky stuff, goes on in hospitals as it does everywhere else, but small things get magnified in the minds of patients and their families, because we’re all helpless without good nurses, and there’s a lot of anxiety running around inside us when someone we love is sick and we can’t make them well by ourselves.

All of this rescuing of Sasha’s foot would not have happened without our new primary care physician (also known as the “family doctor”), who knew the right surgeons to send us to, and spends more time with us every time he visits than any other doctor I’ve ever known.  Not fifteen minutes, but usually a full hour!  He was introduced to us by a dear friend, an addiction and pain specialist named Howard (I’ll write his full name when he gives me permission), when our long-time family doctor left to open a clinic in New Orleans.  This new doctor, Paul Abramson, is a member of The Tribe, and living proof that the universe is occasionally kind and compassionate, despite what might be described as overwhelming evidence to the contrary.  The only negative (which we are going to accept willingly) is that his office is in San Francisco, a near-hour’s drive from our home. Dr. Paul has empathy, intelligence, humor, and loves challenges.  And Sasha’s foot has been quite a challenge, witness the fact that the doctors in the Wound Care Center, where we took Sasha for many months, simply did not see the point of trying to avoid amputation, and thought we were wasting time and money in trying to keep his body intact. A certain lack of imagination, one might say.  They are good doctors, but imaginative they are not.  So I’m saying here, in front of God and all the Little Gods, that we are immensely grateful to Dr. Howard, who led us to Dr. Paul, who led us to Dr. Parrett, who led us to a successful skin graft.

Now, we are going to have to raise enough money to pay for round-the-clock caregivers for Sasha, for what may be years, since that magnificent mind has lost its ability to remember anything that didn’t happen many years ago.  Arteriosclerosis, hardening of the arteries, is the cause, and the only bright spot in this rather sad picture is that Sasha’s true personality — optimistic, pun-loving, people-loving and chemistry-loving — is intact and shining brightly (unless he’s in pain, and we hope that will be an infrequent problem from here on), and when he moves back to the lab, with Paul, our chemist friend and Sasha’s co-author on the Shulgin Index, he’ll be happy again, because he still remembers most of his chemistry, and we hope that will continue for a long, long time.

And the Shulgin Index is off to the printer, thanks mainly to Wendy, my wonderful daughter, who said (something like), “No more!  No more!  It’s finished.  We are sending it out into the big, wide world NOW!”  At which point all the exhausted co-authors (Paul Daley and Tania Manning) cried out in unison (sort of): “Free At Last!  Free At Last!  Thank Wendy Awlmighty, Free At Last!”

Love and Blessings —   Ann